Dr. Stephen Strange (Benedict Cumberbatch) is a reputed neurosurgeon from New York. Everything that he has of brilliant and talented also has it of arrogant and vain. But his life will not be the same after a terrible traffic accident deprives him of the use of his hands. With his damaged hands, he can not exercise his profession and this will ruin his career completely. After several surgical interventions performed by his partner, Dr. Nicodemus West (Michael Stuhlbarg), Stephens hands manage to regain partial mobility, although not the necessary skill to re-operate.
When seeing the traditional medicine failure, Strange is forced to look for a cure and also a hope in a strange place. He will then make a healing trip to the Himalayas, to a mysterious enclave known as Kamar-Taj, where his life will change forever. It will then be when you meet The Elder (Tilda Swinton), who will teach you that the world in which you live is just one reality among many. You will thus discover a hidden world of magical dimensions and, during your training with the mystic master, reveal your psychic powers, such as telepathy, astral projection or teleportation, which you will use to combat evil. Endowed with the magical powers he has just acquired, Strange will be forced to choose between returning to his life of privileges and social status or leaving everything to defend the world from dark and invisible forces willing to destroy our reality.