The series revolves around Dr. Gregory House, a misanthropic medical genius, egotistical and strong and distinct personality who heads the Department of Medical Diagnostic fictional Princeton-Plainsboro Teaching Hospital in New Jersey, led by Dr. Lisa Cuddy. It has two specialties, one in infectious diseases and nephrology another.
Its diagnostic department comprises three or four doctors, in addition to himself, according to the season. Initially the team consisted of Eric Foreman, Allison Cameron and Robert Chase. Then the team members change, integrating doctors Eric Foreman, Lawrence Kutner, Chris Taub Remy Hadley and. Occasionally add one of his few friends, Oncology Hospital chief James Wilson.
The department diagnostics are assigned complex cases that typically face House impersonally, avoiding direct contact with patients, whenever possible. House believes that people tend to lie (everybody lies) and that attitude unsafe, or impossible to discover the truth. Generally, each chapter the team must diagnose a difficult case and it runs through a logical-empirical research process, exposing and discarding various hypotheses, as the events are happening, to solve it.
House is addicted to hydrocodone due to chronic pain in the right leg derived from muscle necrosis, has a misanthropic, ironic character and has a great ability for sarcasm. It shows disrespect for the rules, procedures and protocols, and little interest in performing other various medical tasks to solve complex cases.